Multi-timescale phase-amplitude couplings in transitions of anesthetic-induced unconsciousness
نویسندگان
چکیده
منابع مشابه
Top-down mechanisms of anesthetic-induced unconsciousness
The question of how structurally and pharmacologically diverse general anesthetics disrupt consciousness has persisted since the nineteenth century. There has traditionally been a significant focus on "bottom-up" mechanisms of anesthetic action, in terms of sensory processing, arousal systems, and structural scales. However, recent evidence suggests that the neural mechanisms of anesthetic-indu...
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Davide Gerosa, ∗ Michael Kesden, † Ulrich Sperhake, 3, 4, ‡ Emanuele Berti, 5, § and Richard O’Shaughnessy ¶ Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK Department of Physics, The University of Texas at Dallas, Richardson, TX 75080, USA Department of Physics and Astronomy, The Unive...
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One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable means to study these transitions. Induction of anesthesia is commonly attributed to drug-induced global modulation of neuronal function, while emergence from anesthesia has been thought to occur passively, paralleling elimination of the an...
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Spatial attention is the cognitive function that coordinates the selection of visual stimuli with appropriate behavioral responses. Recent studies have reported that phase-amplitude coupling (PAC) of low and high frequencies covaries with spatial attention, but differ on the direction of covariation and the frequency ranges involved. We hypothesized that distinct phase-amplitude frequency pairs...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-44238-8